Whole Genome Analysis

With expertise in the latest technologies including Illumina* iScan*, Affymetrix GeneChip* and Agilent aCGH, Beckman Coulter Genomics is able to provide flexible and highly powered whole genome analyses that enable the identification of potential biomarkers for disease or drug responses.

By conducting genome wide analysis, we can provide a high throughput solution interrogating up to 2.7 million genetic markers per sample to support genome-wide association studies (GWAS) and copy number variation (CNV) analysis. For these applications, Beckman Coulter Genomics offers a complete genotyping solution using industry leading platforms:

Affymetrix

Affymetrix genome-wide arrays allow the interrogation of the largest set of genetic markers currently available on a single array and facilitate the simultaneous detection of single nucleotide polymorphisms (SNPs) and copy number polymorphisms (CNPs).

Genome-Wide SNP array 6.0
Features more than 1.8 million markers for genetic variation, including more than 906,600 SNPs and more than 946,000 probes for the detection of copy number variation. The cytogenetic protocol for 6.0 SNP genotyping enables CNV and LOH analysis using the Genotyping Console (GTC) Software and provides the ability to analyze small sample numbers (6-22 samples)

Genome-Wide SNP array 5.0
Is a single microarray featuring all single nucleotide polymorphisms (SNPs) from the original two-chip Mapping 500K Array Set, as well as 420,000 additional probes that can measure other genetic differences, such as copy number variation.

Cytogenetics Research Solution
Provides for the analysis of 2.7 million genetic markers and facilitates the characterization of copy number changes, SNP detection, and loss of heterozygosity analysis.

Additional solutions are available using the Affymetrix platform. Please contact Beckman Coulter Genomics for more information.

Agilent

Beckman Coulter Genomics customers interested in comparative genomic hybridization studies for genome-wide analysis of genomic amplifications and deletions can access services based on Agilent Oligo aCGH Microarrays.

Human 1x1M
Over 974,000 oligonucleotide sequences representing coding and non-coding regions with a median probe spacing of 2.1 KB.

Human copy Number Variation (CNV) 2x400K
Over 400,000 oligonucleotide probes targeted against genomic regions with known copy number variation derived from the Database of Genomic Variants, with 1 KB median probe spacing within these regions.

Human High-Resolution Discovery 1x1M
Over 963,000 oligonucleotide probes evenly tiled across the human genome without enrichment for either gene or known CNV regions.

Custom CGH Microarrays
Cost-effective custom content microarrays can be designed to target specific genome regions at virtually any level of resolution.

Illumina

HumanOmni1-Quad
Interrogates more than 1.1 million loci per sample, providing comprehensive genome-wide coverage of SNPs and the ability to detect known and novel CNV regions.

Human660W-Quad
Provides high-density genomic coverage of tag SNPs and markers designed to detect both known and novel CNV regions. It features more than 658,000 evenly spaced tag SNPs derived from HapMap Release 24 data.

HumanCytoSNP-12
Specifically designed for the detection of multiples types of human genomic structural variation, including amplifications, deletions, copy-neutral loss of heterozygosity and mosaicism.